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D-lactate free probiotics – FAQs

The perfect balance of L-lactate and D-lactate

Some people think that probiotics that contain any D-lactate producing strains can cause acidosis. This is too simplistic of an explanation. Together, the eight strains in GutPro™ custom probiotic, along with a proper diet, may be an effective way to correct gut dysbiosis and reverse acidosis


Q. I noticed that GUTPro™ contains L. plantarum that is not D-lactate free. Why?

A. GUTPro™ contains L. plantarum for a very good reason. It has actually been proven to reverse acidosis. L. plantarum initially produces L(+)-lactate, and then switches to producing D(-)-lactate, allowing for equilibrium to be reached. The production of D(-)-lactate in L. plantarum is linked to the biosynthesis of the cell wall.


Q. What about L. salavarius? Is this strain D-lactate free?

A. L. salavarius primarily produces L-lactate and this is why it commonly referred to as “d-lactate free”. But, in reality it does produce a small amount of D-lactate. No studies have shown that this strain has ever caused acidosis. The case is similar with L. gasseri, which predominantly makes L(+)-lactate during the growth phase and switches to D(-)-lactate when the growth cycle plateaus.


Q. I heard that probiotics that contain D-lactate producing strains cause acidosis.

A. Just because a strain produces D-lactate does not mean that it will contribute to acidosis. GutPro™ is formulated with L. plantarum which produces both D-lactate and L-lactate. L. plantarum has actually been proven to reverse acidosis.


Q. Isn’t it true that some probiotics can cause D-lactic acidosis?

A. Yes. Several studies have shown that L. acidophilus has caused acidosis in individuals with compromised digestive systems. That is why GutPro™ was specifically designed without this popular strain of probiotic.


Q. When does D-lactic acidosis occur?

A. D-lactic acidosis occurs when the body is unable to properly metabolize excess D(-)-lactate.


Q. What are the symptoms of D-lactic acidosis?

A. Impaired mental status is a universal feature in D-lactic acidosis. Some of the common neurological symptoms include:

  • Impaired motor coordination
  • Weakness
  • Slurred speech
  • Aggressive or hostile behavior, agitation
  • Stupor, ataxia and gait disturbance
  • Nystagmus (involuntary eye movement)
  • Inability to concentrate
  • Carbohydrate craving
  • Unhappiness and irritability
  • Headache, bruxism and opisthotonus
  • Hyperventilation and tachypnoea
  • Nausea or pallor


Q. What else can contribute to D-lactic acidosis?

  1. Carbohydrate malabsorption
  2. Ingestion of large amounts of carbohydrates
  3. Reduced gut motility
  4. Impaired D(-)-lactate metabolism


Q. Can a urine test diagnosis D-lactic acidosis?

A. Elevated urine D(-)-lactate levels are often confused with D(-)-lactic acidosis. Elevated urine D(-)-lactate levels may be due to a gastrointestinal microbiota predominated by species that produce high amounts of D(-)-lactate.


Q. Can diet help with D-lactic acidosis?

A. The biggest factor in successfully treating D-lactic acidosis is following the proper diet, such as the GAPS Diet  (which was derived from the Specific Carbohydrate Diet - SCD). Simple sugars such as glucose, fructose, and lactose have been shown to promote excessive D(-)-lactate generation by intestinal bacteria and in some cases to precipitate acidotic symptoms.


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